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Antibiotic Resistance History


Antibiotic introduced in yearFirst resistant bacterial strain found in
Penicillin introduced in 1940Penicillin-resistant staph – 1940
Tetracycline introduced in 1950Tetracycline-resistant shigella 1959
Erythromycin introduced in 1953Erythromycin-resistant strep – 1968
Methicillin introduced in 1960Methicillin-resistant staph aureus (MRSA) – 1962
Levofloxacin – 1996Resistant bacteria emerged in – 1996
Linezolid – 2000Resistant bacteria emerged in – 2001
Daptomycin – 2003Resistant bacteria emerged in – 2004

As the above table shows, bacteria are able to develop resistance in a few years after the development of a new antibiotic.

Interestingly, bacteria including Staph Aureus have not been able to develop resistance to silver even though silver has been used for more than 2000 years to fight infection.